Pharmacogenomic testing

Practical, reliable and accurate genetic information for physician success. Knowing genetic profiles helps physicians to adjust drug choices and dosing to improve therapeutic efficacy and reduce adverse drug events.

GenoScribe is a medication risk management tool empowering physicians through simplified genomics.

Genetic variation influences the way drugs are processed and utilized by the body. Pharmacogenomics is the science that explores the effects of specific genetic variants. GenoScribe tests the clinically relevant pharmacogenomic genes in a single, comprehensive test and the GenoScribe™ Genetic Response Report provides the detailed pharmacogenomic results and the correlative clinical effects for individuals. This insightful tool supports the physician in making scientifically reinforced treatment decisions.

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GENOSCRIBE PROVIDES PRACTICAL, RELIABLE, ACCURATE INSIGHTS TO PERSONALIZE DRUG PRESCRIBING.

A patient’s metabolic status is often affected by a change in a single base pair for a gene that codes for a drug-metabolizing enzyme. This gives rise to such patient subgroups as poor metabolizers, rapid metabolizers, and ultra-rapid metabolizers. Each of these subgroups differs in their ability to metabolize certain drugs.

ABNORMAL
Ultra Rapid Metabolizers (UM)

Increased risk of toxicity from a prodrug due to excessive formation of active metabolites. Consider reducing the starting dose and monitor for ADE.

Increased risk of treatment failure from nonprodrugs, consider starting at a higher dose and monitor for lack of efficacy.

ABNORMAL
Intermediate Metabolizers (IM)

Avoid inhibitors, which would functionally result in poor metabolizer ability.

Inducers may improve metabolism.

Inconclusive and varied data, often a reduced dose is suggested with close monitoring for ADE.

NORMAL
Extensive Metabolizers (EM)

Normal drug metabolism should be expected.

ABNORMAL
Poor Metabolizers (PM)

Unlikely to benefit from a prodrug, consider an alternative drug.

Increased risk of toxicity from non-prodrugs, consider reducing the starting dose and monitor for ADE.

With this insight, physicians achieve greater medication tolerability

Now prescribers can more easily choose medication combinations and dosages that are the most efficacious for each patient.

Increase medication
efficacy
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42%

of patients taking prescription pain medication get no relief.

Reduce the risk of Adverse events
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25%

of patients taking prescription medications report an adverse event.

Improve treatment Compliance
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Increase the likelihood of patients adhering to a prescribed regimen.

Integrating pharmacogenetic testing with Medication risk management software.

Introducing genoscribe
And genoscribe live:

GENOSCRIBE: An extensive and unprecedented pharmacogenetic testing service to help physicians personalize treatment and medications based on a patient’s genetics.

GENOSCRIBE LIVE: Going beyond pharmacogenetics, GenoScribe Live is a comprehensive medication risk management tool powered by data, analytics, and scientific research.

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Genoscribe live factors in
  • Pharmacogenetics
  • Demographics
  • Lifestyle
  • Medical Conditions

With GENOSCRIBE LIVE you can assess the treatment plan with the least amount of risk while still accomplishing the intended therapy.

...
EVERY YEAR, MORE THAN 8.6 MILLION ADVERSE DRUG EVENTS (ADES) ARE REPORTED IN THE US — 2.2 MILLION OF THEM ARE SEVERE.

ADEs are the fourth leading cause of death nationwide, after heart disease, cancer, and stroke. Approximately 5 percent of hospital admissions are due to adverse drug events and patients who experienced ADEs were hospitalized an average of 8 to 12 days longer.

Available research shows that much of the variability observed in patient responses to drug therapies is a result of genetics. Pharmacogenetic testing identifies this variability and helps you in the clinical management of your patients.

Using the results from pharmacogenetic testing, prescribing becomes individualized either through a dose adjustment, or selection of alternative therapy.

This tailored approach results in better efficacy and fewer adverse drug reactions.

With genoscribe and Genoscribe live
You can prescribe With confidence.
  • Individualize patient therapies
  • Optimize the safety and efficacy of prescription regimens
  • Reduce adverse drug events
  • Improve treatment compliance and patient outcomes
Who to test?

The vast majority of people have differences in their DNA that impact how they metabolize drugs, which may increase their likelihood of having an adverse drug reaction. Patients who may benefit from PGx testing are:

  • Starting any new medication
  • Experiencing unwanted side effects from any medication
  • On chronic pain medication and/or antidepressants
  • Taking two or more medications
  • Diagnosed with complex chronic diseases:
    • – Arthritis
    • – Cancer
    • – Cardiovascular problems
    • – Diabetes
  • On medications with a possible risk of blood clots
  • On chronic beta-blocker, SSRIs, antiarrhythmic therapy
  • Preparing for a surgical procedure
  • Currently using or starting Plavix or Coumadin
  • Taking certain statin drugs or are candidates for such drugs
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